MLT-747

• Description:

  MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM[1].

• UNSPSC:

  12352005

• Target:

  MALT1

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/MLT-747.html

• Purity:

  99.56

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=CC(Cl)=C(C(N2CCCC2)=O)N=C1)NC3=C([C@@H](OC)C)N4C(N=C3)=CC(Cl)=N4

• Molecular Formula:

  C20H21Cl2N7O3

• Molecular Weight:

  478.33

• References & Citations:

  [1]Quancard J, et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat Chem Biol. 2019 Mar;15 (3) :304-313.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2097853-86-4]