PGN-9856

• Description :

  PGN-9856 is a selective and high affinity (pKi ≥ 8.3) ligand at EP2 receptor. PGN-9856 is a potetn and non-prostanoid EP2 receptor agonist (pEC50 ≥ 8.5) . PGN-9856 shows anti-inflammatory and anti-glaucoma activities[1].

• Product Name Alternative :

  2-Octadecyl-1H-indole-5-carboxylic acid

• UNSPSC :

  12352005

• Target :

  Prostaglandin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/pgn-9856.html

• Purity :

  98.90

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(O)COC1=CC=CC(NC(C2=CC(C3=CC=CC(F)=C3)=CC=C2F)=O)=C1

• Molecular Formula :

  C21H15F2NO4

• Molecular Weight :

  383.34

• References & Citations :

  [1]Coleman RA, et al. The affinity, intrinsic activity and selectivity of a structurally novel EP2 receptor agonist at human prostanoid receptors. Br J Pharmacol. 2019 Mar;176 (5) :687-698.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  EP

• CAS Number :

  [863704-91-0]