GS-9851

CAT: 0804-HY-14308Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-14308Size:1 Each
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Description
GS-9851 (PSI-7851) is an HCV nonstructural protein 5B (NS5B) inhibitor with potential activity for the treatment of HCV infection. GS-9851 showed good tolerability in patients with initial HCV genotype 1 infection. GS-9851 is rapidly cleared from the body with a half-life of approximately 1 hour. The maximum concentration of GS-9851 and the increase in the area under the compound concentration-time curve were not dose-proportional, especially at the highest dose[1].
CAS Number
[1064684-44-1]
Product Name Alternative
PSI-7851
UNSPSC
12352005
Hazard Statement
H315-H317-H319-H335-H360
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gs-9851.html
Smiles
F[C@]1(C)[C@H](O)[C@@H](COP(N[C@H](C(OC(C)C)=O)C)(OC2=CC=CC=C2)=O)O[C@H]1N3C(NC(C=C3)=O)=O
Molecular Formula
C22H29FN3O9P
Molecular Weight
529.45
Precautions
P261-P264-P271-P272-P280-P302+P352-P304+P340-P362+P364-P405-P501
References & Citations
[1]Discovery of a β-D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus J. Med. Chem., Article ASAP DOI: 10.1021/jm100863x Publication Date (Web) : September 16, 2010|[2]Pharmacokinetics, pharmacodynamics, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor, following multiple ascending doses in patients with chronic hepatitis C infection
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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