ELA-21 (human)

• UNSPSC Description:

  ELA-21 (human) is an apelin receptor agonist with a pKi of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways[1].

• Target Antigen:

  Apelin Receptor (APJ); Arrestin

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/ela-21-human.html

• Purity:

  98.92

• Solubility:

  H2O : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(N1[C@@H](CCC1)C(O)=O)[C@H](CC2=CC=CC=C2)NC([C@H]3N(CCC3)C([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@H](CC(C)C)NC([C@H]4N(CCC4)C([C@H](CCSC)NC([C@H]5NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC5)NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(C)C)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)CC(C)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)CC7=CN=CN7)=O)=O)=O)=O)=O

• Molecular Weight:

  2587.11

• References & Citations:

  [1]Peiran Yang, et al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017 Mar 21;135(12):1160-1173.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  2245073-05-4