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ELA-21 (human)

CAT: 0804-HY-P2249-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2249-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ELA-21 (human) is an apelin receptor agonist with a pKi of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways[1].
CAS Number
2245073-05-4
UNSPSC
12352209
Target
Apelin Receptor (APJ) ; Arrestin
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ela-21-human.html
Purity
99.97
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](CCC1)C(O)=O)[C@H](CC2=CC=CC=C2)NC([C@H]3N(CCC3)C([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@H](CC(C)C)NC([C@H]4N(CCC4)C([C@H](CCSC)NC([C@H]5NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC5)NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(C)C)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)CC(C)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)CC7=CN=CN7)=O)=O)=O)=O)=O
Molecular Formula
C112H184N40O25S3
Molecular Weight
2587.11
References & Citations
[1]Peiran Yang, et al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017 Mar 21;135 (12) :1160-1173.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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