ELA-11(human)

ELA-11(human)

• CAS Number: 1784687-32-6
• UNSPSC Description: ELA-11(human), a peptide, is a full agonist of human apelin receptor, with a pKi of 7.85. ELA-11(human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment[1].
• Target Antigen: Apelin Receptor (APJ); Arrestin
• Type: Peptides
• Related Pathways: GPCR/G Protein
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/ela-11-human.html
• Purity: 99.03
• Solubility: H2O : 100 mg/mL (ultrasonic)
• Smiles: O=C(N1[C@@H](CCC1)C(O)=O)[C@H](CC2=CC=CC=C2)NC([C@H]3N(CCC3)C([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@H](CC(C)C)NC([C@H]4N(CCC4)C([C@H](CCSC)NC([C@@H](N)CS)=O)=O)=O)=O)CC5=CN=CN5)=O)=O)=O)=O)=O
• Molecular Weight: 1283.56
• References & Citations: [1]Yang P, et, al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017 Mar 21;135(12):1160-1173.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
• Clinical Information: No Development Reported