ELA-11 (human)

CAT: 0804-HY-P2197-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-P2197-01Size:1 mg

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Description

ELA-11 (human), a peptide, is a full agonist of human apelin receptor, with a pKi of 7.85. ELA-11 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment[1].

CAS Number

1784687-32-6

UNSPSC

12352209

Target

Apelin Receptor (APJ) ; Arrestin

Type

Peptides

Related Pathways

GPCR/G Protein

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ela-11-human.html

Purity

99.54

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N1[C@@H](CCC1)C(O)=O)[C@H](CC2=CC=CC=C2)NC([C@H]3N(CCC3)C([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@H](CC(C)C)NC([C@H]4N(CCC4)C([C@H](CCSC)NC([C@@H](N)CS)=O)=O)=O)=O)CC5=CN=CN5)=O)=O)=O)=O)=O

Molecular Formula

C58H90N16O13S2

Molecular Weight

1283.56

References & Citations

[1]Yang P, et, al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017 Mar 21;135 (12) :1160-1173.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Scientific Category

Peptides

Clinical Information

No Development Reported

Chemical Information

Elabela/Toddler-11

CAS Number	1784687-32-6
PubChem CID	127043376
IUPAC Name	(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carboxylic acid
Molecular Formula	C58H90N16O13S2
Molecular Weight	1283.6
XLogP	-2.7
Topological Polar Surface Area	468
Hydrogen Bond Donor Count	14
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	34
Heavy Atom Count	89
Formal Charge	0
Complexity	2470

SMILES

CC(C)C[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N4CCC[C@H]4C(=O)O)NC(=O)[C@@H]5CCCN5C(=O)[C@H](CCSC)NC(=O)[C@H](CS)N

InChI

InChI=1S/C58H90N16O13S2/c1-32(2)25-39(68-52(81)43-16-10-21-72(43)54(83)38(19-24-89-5)66-47(76)36(59)30-88)49(78)67-40(27-35-28-62-31-64-35)50(79)70-42(29-75)51(80)65-37(15-9-20-63-58(60)61)48(77)71-46(33(3)4)56(85)73-22-11-17-44(73)53(82)69-41(26-34-13-7-6-8-14-34)55(84)74-23-12-18-45(74)57(86)87/h6-8,13-14,28,31-33,36-46,75,88H,9-12,15-27,29-30,59H2,1-5H3,(H,62,64)(H,65,80)(H,66,76)(H,67,78)(H,68,81)(H,69,82)(H,70,79)(H,71,77)(H,86,87)(H4,60,61,63)/t36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1

InChIKey

XXKPNJFJXZBRMX-HDKAIKTRSA-N

Chemical Structure

2D Structure

CAS: 1784687-32-6

CID: 127043376

Formula: C58H90N16O13S2

MW: 1283.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	1283.6
XLogP3	-2.7
Hydrogen Bond Donor Count	14
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	34
Exact Mass	1282.63146934
Monoisotopic Mass	1282.63146934
Topological Polar Surface Area	468 Å²
Heavy Atom Count	89
Formal Charge	0
Complexity	2470
Isotope Atom Count	0
Defined Atom Stereocenter Count	11
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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JWC68732-01	Ela-11 (human)
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A23457-5	ELA-11 (human) 5mg
T76053-01	ELA-11 (human) TFA
A23457-10	ELA-11 (human) 10mg
A23457-1	ELA-11 (human) 1mg
LAD97305-01	ELA-14 (human)
TP2096	ELA-21 (human)
FSC20579	ELA-32 (human)
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ELA-11 (human)

Chemical Information

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