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GNE-490

CAT: 0804-HY-10812-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10812-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNE-490, a (thienopyrimidin-2-yl) aminopyrimidine, is a potent pan-PI3K inhibitor with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50=750 nM) . GNE-490 shows potent suppression efficacy profile against MCF7.1 breast cancer xenograft model[1].
CAS Number
1033739-92-2
UNSPSC
12352005
Target
MTOR; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gne-490.html
Purity
96.29
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC(C)(C)C1=CC(N=C(C2=CN=C(N)N=C2C)N=C3N4CCOCC4)=C3S1
Molecular Formula
C18H22N6O2S
Molecular Weight
386.47
References & Citations
[1]Daniel P Sutherlin, et al. Discovery of (thienopyrimidin-2-yl) aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer. J Med Chem. 2010 Feb 11;53 (3) :1086-97.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

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Alternative Products

CatalogName
BA8717-5GNE-490
A22231-50GNE-490 50mg
A22231-25GNE-490 25mg
A22231-1GNE-490 1mg
A22231-200GNE-490 200mg
A22231-100GNE-490 100mg
A22231-10GNE-490 10mg
A22231-5GNE-490 5mg
A22231-2GNE-490 2mg
A22231-10mM-DGNE-490 10mM * 1mL in DMSO

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