Caloxin 1C2

• UNSPSC Description:

  Caloxin 1C2 is a specific PMCA (plasma-membrane Ca2+-ATPases) inhibitor. Caloxin 1C2 is selective for PMCA4 over PMCA1, 2 and 3. The Ki values of Caloxin 1C2 are 2.3 μM for PMCA4 and 21 μM for PMCA1. Caloxin 1C2 dose not cause any significant effects on total Ca2+ transfer. Caloxin 1C2 affects coronary contractility[1][2].

• Target Antigen:

  Calcium Channel; Proton Pump

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/caloxin-1c2.html

• Smiles:

  O=C(N[C@@H](C)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N

• Molecular Weight:

  1844.08

• References & Citations:

  [1]Sillanpää JK, et al. Calcium transfer across the outer mantle epithelium in the Pacific oyster, Crassostrea gigas. Proc Biol Sci. 2018 Nov 14;285(1891):20181676.|[2]Pande J, et al. Functional effects of caloxin 1c2, a novel engineered selective inhibitor of plasma membrane Ca(2+)-pump isoform 4, on coronary artery. J Cell Mol Med. 2008 Jun;12(3):1049-60.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported