Caloxin 1b3

• Description:

  Caloxin 1b3, a peptide, is a selective plasma membrane Ca2+ pump 1 (PMCA1) inhibitor. Caloxin 1b3 significantly inhibits PMCA1 Ca2+–Mg2+-ATPase in the rabbit duodenal mucosa than the PMCA4 in the human erythrocyte ghosts. Caloxin 1b3 also increases cytosolic Ca2+ concentration in endothelial cells. Caloxin 1b3 can be used for cardiovascular disorders research[1].

• UNSPSC:

  12352209

• Target:

  Calcium Channel

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=C (N[C@@H] ([C@@H] (C) CC) C (N1[C@@H] (CCC1) C (N[C@@H] (CCCCN) C (N[C@@H] (CC2=CNC3=CC=CC=C23) C (N[C@@H] ([C@@H] (C) CC) C (N[C@@H] (CO) C (N[C@@H] ([C@@H] (C) CC) C (N[C@@H] ([C@@H] (C) CC) C (N[C@@H] (CCC (N) =O) C (N[C@@H] (C) C (N[C@@H] (CC (C) C) C (N[C@@H] (CCCNC (N) =N) C (NCC (NCC (NCC (N[C@@H] (CO) C (N[C@@H] (CCCCN) C (N) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) [C@H] ([C@H] (O) C) N

• Molecular Formula:

  C88H150N26O22

• Molecular Weight:

  1924.29

• References & Citations:

  [1]Szewczyk MM, et al. Caloxin 1b3: a novel plasma membrane Ca (2+) -pump isoform 1 selective inhibitor that increases cytosolic Ca (2+) in endothelial cells. Cell Calcium. 2010 Dec;48 (6) :352-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported