MAPK-IN-5

• Target:

  ROS|||p38 MAPK|||Caspase|||PARP|||Bcl-2 Family|||Apoptosis

• Related Pathways:

  DNA Damage/DNA Repair|||Proteases/Proteasome|||Apoptosis|||Immunology/Inflammation|||Chromatin/Epigenetic|||MAPK

• Bioactivity:

  MAPK-IN-5 is a potent inhibitor of MAPK, with an IC50 value of 1.35 ?M in HeLa cells. It induces ROS-mediated DNA damage and mitochondrial apoptosis (apoptosis) via the MAPK pathway. MAPK-IN-5 significantly inhibits colony formation in HeLa cells, reduces viable cell numbers, suppresses cell migration, and arrests the cell cycle at the G2/M phase. It is applicable in cervical cancer research.

• Smiles:

  FC (F) (F) C1=CC=C (C=C1) CN2N=NC (=C2) C=3C=CC=C (C3) NC=4N=CN=C5C=C (OCCOC) C (OCCOC) =CC54

• Molecular Formula:

  C30H29F3N6O4

• Molecular Weight:

  594.58

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2579683-39-7