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MAPK-IN-5

CAT: 0804-HY-175175Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175175Size:1 Each
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Description
MAPK-IN-5 is a potent MAPK inhibitor with an IC50 of 1.35 μM against HeLa cells. MAPK-IN-5 inhibits HeLa cell proliferation by inducing ROS-mediated DNA damage and mitochondrial apoptosis via the MAPK pathway. MAPK-IN-5 significantly inhibits colony formation, reduces the number of live cells, suppresses cell migration, and causes cell cycle arrest in the G2/M phase in HeLa cells. MAPK-IN-5 can be used for the study of cervical cancer[1].
CAS Number
2579683-39-7
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; p38 MAPK; PARP; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COCCOC(C=C1N=CN=C2NC3=CC(C(N=N4)=CN4CC5=CC=C(C(F)(F)F)C=C5)=CC=C3)=C(C=C12)OCCOC
Molecular Formula
C30H29F3N6O4
Molecular Weight
594.58
References & Citations
[1]Wang L, et al. Design, synthesis and anti-cancer activity of novel 1,2,3-triazole hybrids of erlotinib against cervical cancer via MAPK signaling pathway. Sci Rep. 2025 Jul 9;15 (1) :24582.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Caspase 3; Caspase 9; p38 MAPK; PARP1

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