ATX-002

• Description:

  ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively[1].

• UNSPSC:

  12352211

• Target:

  Liposome

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/atx-002.html

• Purity:

  98.0

• Solubility:

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CN(C)CCSC(N(CCCCCCCC(OC/C=C\CCCCCC)=O)CCCCCCCC(OC/C=C\CCCCCC)=O)=O

• Molecular Formula:

  C39H72N2O5S

• Molecular Weight:

  681.06

• References & Citations:

  [1]Rajappan K, et al. Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA. J Med Chem. 2020 Nov 12;63 (21) :12992-13012. |[2]Ramaswamy S, et al., Systemic delivery of factor IX messenger RNA for protein replacement therapy. Proc Natl Acad Sci U S A. 2017 Mar 7;114 (10) :E1941-E1950.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1777792-34-3]