ATX-IN-1
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
ATX-IN-1
Target :
PDERelated Pathways :
MetabolismBioactivity :
ATX-IN-1 (compound 35) is an ATX inhibitor with an IC50 of 0.7 nM, demonstrating anti-inflammatory properties. It effectively suppresses the TGF-?/Smad pathway and reduces collagen deposition, alleviating fibrosis in a Bleomycin-induced mouse model. This compound also exhibits good oral bioavailability (F=69.5%) and microsomal stability.Molecular Formula :
C25H22N6O5Molecular Weight :
486.48Shipping Conditions :
Cool packStorage Temperature :
-20°C
