ATX-1905

• Description :

  ATX-1905 is a positron emission tomography (PET) tracer that demonstrates good autotaxin (ATX) binding specificity and achieves semiquantification of lung ATX expression levels, which are elevated in fibrotic lungs. ATX-1905 exhibits elevated uptake in Bleomycin (HY-108345) -induced pulmonary fibrosis (BPF) lungs. ATX-1905 is promising for research of idiopathic pulmonary fibrosis (IPF) [1].

• UNSPSC :

  12352005

• Target :

  Phosphodiesterase (PDE)

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Others

• Smiles :

  [2H]C(Cl)(C([2H])(N1CCN(CC1)C(CN2CCN(CC2)C3=CN4C(C=C3)=NC(CC)=C4N(C5=NC(C6=CC=C(C=C6)F)=C(S5)C#N)C)=O)[2H])[2H]

• Molecular Formula :

  C32H33D4ClFN9OS

• Molecular Weight :

  654.24

• References & Citations :

  [1]Deng X, et al. Imaging Pulmonary Fibrosis and Treatment Efficacy In Vivo with Autotaxin-Specific PET Ligand [18F]ATX-1905. Mol Pharm. 2024 Aug 26.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [3035983-65-1]