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ATX L1

CAT: 0013-GTR19259813-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19259813-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L1 is a biodegradable, branched self-immolative lipid optimized for ​​high-efficiency mRNA delivery​​. Its disulfide-based architecture enables rapid glutathione-triggered degradation in the cytosol (liver half-life: 4.2 days), promoting rapid clearance while maintaining serum stability. In vivo, L1 achieves ​​exceptional mRNA translation​​, producing twice the hEPO protein levels of the clinically approved MC3 lipid at 0.1 mg/kg. Its apparent pKa (6.57) facilitates efficient endosomal escape without compromising safety: even at 5 mg/kg, L1 causes no significant body weight loss or sustained inflammation. Structural features (C7 alkyl tails, carbamate linker) balance potency and biodegradability, making L1 ideal for mRNA vaccines and protein-replacement therapies.
Purity
>98%
Smiles
CCCCCCCC (CCCCCCC) OC (=O) CCCN (CCCC (=O) OC (CCCCCCC) CCCCCCC) C (=O) OCCSSCCCN (C) C
Molecular Formula
C46H90O6N2S2
Molecular Weight
831.35
Notes
For research use only.

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