ATX-IN-3

CAT: 0804-HY-175537Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-175537Size:1 Each

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Description

ATX-IN-3 is an orally active autotaxin (ATX) inhibitor with an IC50 of 46 nM. ATX-IN-3 certainly reduces collagen deposition and ameliorates lung fibrosis in the pulmonary fibrosis mouse model. ATX-IN-3 has good metabolic stability and drug-like properties. ATX-IN-3 can used for the study of idiopathic pulmonary fibrosis (IFP) [1].

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

FC1=CC=C(C(N2CC(N3CCC(C4=NC5=C(C=CC(NC(C6=CC=CO6)=O)=C5)N4)CC3)(CC#N)C2)=O)C=C1

Molecular Formula

C29H27FN6O3

Molecular Weight

526.56

References & Citations

[1]Zhao B, et al. Rational design and identification of potent imidazole-fused Autotaxin inhibitors for treatment of idiopathic pulmonary fibrosis. Eur J Med Chem. 2025 Nov 15;298:118011.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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T212168-01	ATX-IN-3
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T84678-01	ATX-001
sc-396801	ATX-II
OR1005041-01	ATX-0126
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GTR19259813-01	ATX L1
TYD-04105-01	ATX-95

ATX-IN-3

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