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ARP-100

CAT: 0804-HY-103444-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103444-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM) . ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM) [1][2].
CAS Number
704888-90-4
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/arp-100.html
Concentration
10mM
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NO)CN(S(=O)(C1=CC=C(C2=CC=CC=C2)C=C1)=O)OC(C)C
Molecular Formula
C17H20N2O5S
Molecular Weight
364.42
Precautions
H228, H315, H319
References & Citations
[1]Rossello A, et al. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) . Bioorg Med Chem. 2004 May 1;12 (9) :2441-50.|[2]Tuccinardi T, et al. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R) - and (S) -N-hydroxy-2- (N-isopropoxybiphenyl-4-ylsulfonamido) -3-methylbutanamides. Bioorg Med Chem. 2006 Jun 15;14 (12) :4260-76.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-1; MMP-2; MMP-3; MMP-7; MMP-9

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