ARP-100

• Description:

  ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM) . ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM) [1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H228, H315, H319

• Target:

  MMP

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/arp-100.html

• Concentration:

  10mM

• Purity:

  99.0

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(NO)CN(S(=O)(C1=CC=C(C2=CC=CC=C2)C=C1)=O)OC(C)C

• Molecular Formula:

  C17H20N2O5S

• Molecular Weight:

  364.42

• Precautions:

  H228, H315, H319

• References & Citations:

  [1]Rossello A, et al. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) . Bioorg Med Chem. 2004 May 1;12 (9) :2441-50.|[2]Tuccinardi T, et al. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R) - and (S) -N-hydroxy-2- (N-isopropoxybiphenyl-4-ylsulfonamido) -3-methylbutanamides. Bioorg Med Chem. 2006 Jun 15;14 (12) :4260-76.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MMP-1; MMP-2; MMP-3; MMP-7; MMP-9

• CAS Number:

  [704888-90-4]