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EGFR-IN-100

CAT: 0804-HY-161146Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161146Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-100 (compound 3f) is a EGFR inhibitor with IC50 range of 0.137-0.507 μM. EGFR-IN-100 has antiproliferative activity and induces the apoptosis pathway. EGFR-IN-100 arrests the MCF-7 cell cycle at the S phase[1].
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-100.html
Solubility
10 mM in DMSO
Smiles
N=C(SC1=NC(C2=CC=CC=C2)(C3=CC=CC=C3)C(N1)=O)/C(C#N)=C/C4=CC=CS4
Molecular Formula
C23H16N4OS2
Molecular Weight
428.53
References & Citations
[1]Fatma G Abdulrahman, et al. Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers. Bioorg Chem. 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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