AKT-100

CAT: 0804-HY-179129Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179129Size:1 Each
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Description
AKT-100 is a p53 reactivation agent. AKT-100 significantly inhibits the proliferation of various ovarian and endometrial cancer cells at low concentrations. AKT-100 can upregulate cell cycle regulatory genes (such as p21, GADD45) and pro apoptotic genes (such as NOXA, DR5), and inhibit DNA repair pathways. AKT-100 is commonly used in cancer research[1].
CAS Number
[3076960-67-0]
UNSPSC
12352005
Target
MDM-2/p53
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(/C(CN(C(CNC1C(C)(C)N([O])C(C)(C)C1)=O)C/2)=C/C3=CC=C(C#N)C=C3)C2=C\C4=CC=C(C#N)C=C4
Molecular Formula
C31H32N5O3
Molecular Weight
522.62
References & Citations
[1]Williams G L, et al. The novel curcumin analogue AKT-100 targets mutant p53 in gynecologic cancer cells[J]. bioRxiv, 2025: 2025.10. 06.680794.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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