AKT-100

• Description :

  AKT-100 is a p53 reactivation agent. AKT-100 significantly inhibits the proliferation of various ovarian and endometrial cancer cells at low concentrations. AKT-100 can upregulate cell cycle regulatory genes (such as p21, GADD45) and pro apoptotic genes (such as NOXA, DR5), and inhibit DNA repair pathways. AKT-100 is commonly used in cancer research[1].

• UNSPSC :

  12352005

• Target :

  MDM-2/p53

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C(/C(CN(C(CNC1C(C)(C)N([O])C(C)(C)C1)=O)C/2)=C/C3=CC=C(C#N)C=C3)C2=C\C4=CC=C(C#N)C=C4

• Molecular Formula :

  C31H32N5O3

• Molecular Weight :

  522.62

• References & Citations :

  [1]Williams G L, et al. The novel curcumin analogue AKT-100 targets mutant p53 in gynecologic cancer cells[J]. bioRxiv, 2025: 2025.10. 06.680794.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3076960-67-0]