GANT 61

• UNSPSC Description:

  GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.

• Target Antigen:

  Autophagy; Gli

• Type:

  Reference compound

• Related Pathways:

  Autophagy;Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/GANT-61.html

• Smiles:

  CN(C)C1=CC=CC=C1CN2C(C3=CC=NC=C3)N(CC4=CC=CC=C4N(C)C)CCC2

• Molecular Weight:

  429.60

• References & Citations:

  [1]Mazumdar T, et al. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res. 2011 Feb 1;71(3):1092-102.|[2]Fu J, et al. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 2013 Mar 1;330(1):22-32.|[3]Wickstrom M, et al. Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. Int J Cancer. 2013 Apr 1;132(7):1516-24.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  500579-04-4