GANT 61

• Description :

  GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.

• Product Name Alternative :

  NSC 136476

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H319

• Target :

  Autophagy; Gli

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/GANT-61.html

• Purity :

  99.80

• Solubility :

  DMSO : 25 mg/mL (ultrasonic) |Ethanol : 66.67 mg/mL (ultrasonic)

• Smiles :

  CN(C)C1=CC=CC=C1CN2C(C3=CC=NC=C3)N(CC4=CC=CC=C4N(C)C)CCC2

• Molecular Formula :

  C27H35N5

• Molecular Weight :

  429.60

• Precautions :

  H302, H319

• References & Citations :

  [1]Mazumdar T, et al. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res. 2011 Feb 1;71 (3) :1092-102.|[2]Fu J, et al. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 2013 Mar 1;330 (1) :22-32.|[3]Wickstrom M, et al. Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. Int J Cancer. 2013 Apr 1;132 (7) :1516-24.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [500579-04-4]