RUPB-61

• Description :

  RUPB-61 is a potent Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) inhibitor with an IC50 value of 13 nM. RUPB-61 shows antiparasitic activity[1].

• UNSPSC :

  12352005

• Target :

  Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/pfpkg-in-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC(C=C1)=CC=C1C(NC([C@@H]2[C@H](C)CN(C)CC2)=C3)=C3C4=CC=NC=C4

• Molecular Formula :

  C22H24FN3

• Molecular Weight :

  349.44

• References & Citations :

  [1]Gilleran JA, et al. Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials. J Med Chem. 2024 Feb 19.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported