GANT 58

• Description :

  GANT 58 (NSC 75503) is a potent GLI antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM[1].

• Product Name Alternative :

  NSC 75503

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Gli

• Type :

  Reference compound

• Related Pathways :

  Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/GANT-58.html

• Purity :

  99.37

• Solubility :

  DMSO : 9.09 mg/mL (ultrasonic) |Ethanol : 20 mg/mL (ultrasonic)

• Smiles :

  C1(C2=C(C(C3=CC=NC=C3)=C(S2)C4=CC=NC=C4)C5=CC=NC=C5)=CC=NC=C1

• Molecular Formula :

  C24H16N4S

• Molecular Weight :

  392.48

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Lauth M, et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A. 2007 May 15;104 (20) :8455-60.|[2]Joo J, et al. GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS One. 2009 Oct 27;4 (10) :e7608.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [64048-12-0]