ARD-61

CAT: 0804-HY-139659-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-139659-01Size:1 mg
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Description
ARD-61 is a highly potent, effective and specific PROTAC androgen receptor (AR) degrader. ARD-61 potently and effectively induces AR and progesterone receptors (PR) degradation in AR+ cancer cell lines. ARD-61 induces apoptosis and effectively induces tumor growth inhibition in the MDA-MB-453 xenograft model in mice[1]. ARD-61 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[2316837-08-6]
UNSPSC
12352005
Target
Androgen Receptor; Apoptosis; Progesterone Receptor; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ard-61.html
Purity
99.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)([C@H](C1(C)C)NC(C2=CC=C(C=C2)C#CC3CCN(C4CCN(CC4)C(C[C@@H](C5=CC=C(C6=C(C)N=CS6)C=C5)NC([C@H]7N(C[C@@H](C7)O)C([C@@H](C8=CC(C)=NO8)C(C)C)=O)=O)=O)CC3)=O)[C@H]1OC9=CC(Cl)=C(C=C9)C#N
Molecular Formula
C61H71ClN8O7S
Molecular Weight
1095.78
References & Citations
[1]Lijie Zhao, et al. A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo. Neoplasia. 2020 Oct;22 (10) :522-532.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)

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