ARD-61

• Description :

  ARD-61 is a highly potent, effective and specific PROTAC androgen receptor (AR) degrader. ARD-61 potently and effectively induces AR and progesterone receptors (PR) degradation in AR+ cancer cell lines. ARD-61 induces apoptosis and effectively induces tumor growth inhibition in the MDA-MB-453 xenograft model in mice[1]. ARD-61 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC :

  12352005

• Target :

  Androgen Receptor; Apoptosis; Progesterone Receptor; PROTACs

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; PROTAC; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ard-61.html

• Purity :

  99.57

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(C)([C@H](C1(C)C)NC(C2=CC=C(C=C2)C#CC3CCN(C4CCN(CC4)C(C[C@@H](C5=CC=C(C6=C(C)N=CS6)C=C5)NC([C@H]7N(C[C@@H](C7)O)C([C@@H](C8=CC(C)=NO8)C(C)C)=O)=O)=O)CC3)=O)[C@H]1OC9=CC(Cl)=C(C=C9)C#N

• Molecular Formula :

  C61H71ClN8O7S

• Molecular Weight :

  1095.78

• References & Citations :

  [1]Lijie Zhao, et al. A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo. Neoplasia. 2020 Oct;22 (10) :522-532.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Von Hippel-Lindau (VHL)

• CAS Number :

  [2316837-08-6]