Iminostilbene-d10

• Description:

  Iminostilbene-d10 is the deuterium labeled Iminostilbene (HY-N7064) . Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2) . Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases[1][2].

• UNSPSC:

  12352005

• Target:

  COX; HIF/HIF Prolyl-Hydroxylase; Interleukin Related; Isotope-Labeled Compounds; NO Synthase; Pyruvate Kinase; STAT; TNF Receptor

• Related Pathways:

  Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt

• Field of Research:

  Inflammation/Immunology

• Smiles:

  [2H]C1=C(C2=C(NC3=C1C([2H])=C(C([2H])=C3[2H])[2H])C([2H])=C([2H])C([2H])=C2[2H])[2H]

• Molecular Formula:

  C14HD10N

• Molecular Weight:

  203.31

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [3044090-39-0]