Iminostilbene

• Description:

  Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2) . Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H401, H411

• Target:

  COX; HIF/HIF Prolyl-Hydroxylase; Interleukin Related; NO Synthase; Pyruvate Kinase; STAT; TNF Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/iminostilbene.html

• Purity:

  99.34

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  C12=CC=CC=C1C=CC3=CC=CC=C3N2

• Molecular Formula:

  C14H11N

• Molecular Weight:

  193.25

• Precautions:

  H302, H401, H411

• References & Citations:

  [1]Christian P, et al. Crystallization of Carbamazepine in Proximity to Its Precursor Iminostilbene and a Silica Surface. Cryst Growth Des. 2016 May 4;16 (5) :2771-2778. Epub 2016 Mar 30.|[2]Lu S, et al. Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia-reperfusion injury. J Adv Res. 2020 Sep 9;29:83-94.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  COX-2; HIF-1α; iNOS; STAT3

• CAS Number:

  [256-96-2]