Cetrorelix-d10

• Description :

  Cetrorelix-d10 (SB-75-d10) is deuterium labeled Cetrorelix. Cetrorelix is a potent gonadotrophin-releasing hormone (GnRH) antagonist. Cetrorelix inhibits the endogenous luteinizing hormone surge during ovarian stimulation. Cetrorelix reduces cyclophosphamide induced ovarian follicular destruction in mice[1][2].

• Product Name Alternative :

  SB-75-d10

• UNSPSC :

  12352005

• Target :

  GnRH Receptor; Isotope-Labeled Compounds

• Related Pathways :

  GPCR/G Protein; Others

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology

• Smiles :

  OC1=CC=C(C[C@@H](C(N[C@@H](C(N[C@]([2H])(C(N[C@H](C(N2[C@H](C(N[C@@H](C(N)=O)C)=O)CCC2)=O)CCCNC(N)=N)=O)C([2H])(C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])[2H])=O)CCCNC(N)=O)=O)NC([C@@H](NC([C@@H](CC3=CN=CC=C3)NC([C@@H](CC4=CC=C(Cl)C=C4)NC([C@@H](CC5=CC6=C(C=C5)C=CC=C6)NC(C)=O)=O)=O)=O)CO)=O)C=C1

• Molecular Formula :

  C70H82D10ClN17O14

• Molecular Weight :

  1441.10

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Diedrich K, et al. Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist Cetrorelix during ovarian stimulation. Hum Reprod. 1994 May;9 (5) :788-91. |[3]Meirow D, et al. The GnRH antagonist cetrorelix reduces cyclophosphamide-induced ovarian follicular destruction in mice. Hum Reprod. 2004 Jun;19 (6) :1294-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported