TDHL

• Description :

  TDHL (Tergurid) is a dopamine receptor agonist with a Kd of 0.39 nM for D2 receptor and an orally available 5-HT-2 receptor antagonist.

• CAS Number :

  [37686-84-3]

• Product Name Alternative :

  Tergurid; Terguride; trans-Dihydrolisuride

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H311, H331

• Target :

  5-HT Receptor; Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/TDHL.html

• Purity :

  99.9

• Solubility :

  10 mM in DMSO

• Smiles :

  CN1[C@@]2([H])[C@@](C[C@@H](C1)NC(N(CC)CC)=O)([H])C3=CC=CC4=C3C(C2)=CN4

• Molecular Formula :

  C20H28N4O

• Molecular Weight :

  340.46

• Precautions :

  H301, H311, H331

• References & Citations :

  [1]Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340 (2) :369-76.|[2]Mizokawa T, et al. Terguride as a new anti-hyperprolactinemic agent: characterization in rats and dogs in comparison with bromocriptine. Jpn J Pharmacol. 1993 Nov;63 (3) :269-78.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2