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SC-60

CAT: 0804-HY-W717425Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W717425Size:1 Each
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SC-60 is a derivative of Sorafenib (HY-10201) . SC-60 exerts its anti-tumor effect by activating the phosphatase activity of SHP-1, thereby inhibiting the STAT3 signaling pathway. SC-60 exhibits strong proliferation inhibitory activity in various hepatocellular carcinoma (HCC) cell lines. SC-60 downregulates the expression of downstream anti-apoptotic proteins (such as Bcl-2, Cyclin D1, Survivin), ultimately inducing caspase-dependent apoptosis. SC-60 significantly inhibits tumor growth in xenograft tumor models. SC-60 can be used for the study of HCC[1].
CAS Number
[1421677-31-7]
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; CDK; Drug Derivative; SHP1; STAT; Survivin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
N#CC1=CC=C(C=C1)OC2=CC(NC(NC3=CC=C(C)C(OC4=CC=C(C=C4)C#N)=C3)=O)=CC=C2C
Molecular Formula
C29H22N4O3
Molecular Weight
474.51
References & Citations
[1]Tai WT, et al. SC-60, a dimer-based sorafenib derivative, shows a better anti-hepatocellular carcinoma effect than sorafenib in a preclinical hepatocellular carcinoma model. Mol Cancer Ther. 2014 Jan;13 (1) :27-36.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; STAT3

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