SC-53606

• Description :

  SC-53606 is a potent and selective 5-HT4 receptor antagonist, with a pA2 value of 8.13. SC-53606 acts as an antagonist of 5-HT4 receptor-mediated relaxation of Carbachol (HY-B1208) -induced contractions[1][2].

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C(NC[C@H]1[C@@]2(CCCN2CC1)[H])C3=CC(Cl)=CN4C3=NC=C4

• Molecular Formula :

  C16H19ClN4O

• Molecular Weight :

  318.80

• References & Citations :

  [1]Yang DC, et al. SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophageal tunica muscularis mucosae. J Pharmacol Exp Ther. 1993 Sep;266 (3) :1339-47.|[2]Becker D P, et al. Design and synthesis of agonists and antagonists of the serotonin 5-HT4 receptor subtype. Pharmacochemistry Library. Elsevier, 1996, 24: 99-120.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT4 Receptor

• CAS Number :

  [151898-33-8]