SC-53606

• Description:

  SC-53606 is a potent and selective 5-HT4 receptor antagonist, with a pA2 value of 8.13. SC-53606 acts as an antagonist of 5-HT4 receptor-mediated relaxation of Carbachol (HY-B1208) -induced contractions[1][2].

• UNSPSC:

  12352005

• Target:

  5-HT Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C (NC[C@H]1[C@@]2 (CCCN2CC1) [H]) C3=CC (Cl) =CN4C3=NC=C4

• Molecular Formula:

  C16H19ClN4O

• Molecular Weight:

  318.80

• References & Citations:

  [1]Yang DC, et al. SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophageal tunica muscularis mucosae. J Pharmacol Exp Ther. 1993 Sep;266 (3) :1339-47.|[2]Becker D P, et al. Design and synthesis of agonists and antagonists of the serotonin 5-HT4 receptor subtype. Pharmacochemistry Library. Elsevier, 1996, 24: 99-120.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT4 Receptor

• CAS Number:

  151898-33-8