NIP 142

CAT: 0804-HY-W705705Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W705705Size:1 Each
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Description
NIP-142 is a benzopyran derivative with multiple ion channel-blocking effects. NIP-142 selectively blocks the potassium ion channels enriched in atrial muscle, prolonging the effective refractory period (ERP) and action potential duration (APD) of the atrium, while having minimal effect on ventricular repolarization. NIP-142 also inhibits L-type/T-type calcium channels and sodium channels, further contributing to its anti-arrhythmic effect. NIP-142 shows significant efficacy in various atrial fibrillation models. NIP-142 can be used for research on arrhythmias[1].
CAS Number
[203002-58-8]
UNSPSC
12352005
Target
Calcium Channel; Potassium Channel; Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
COC(C=C1)=CC=C1CC(NC2=C([N+]([O-])=O)C=C(OC(C)([C@@H]3O)C)C([C@@H]3NC4CC4)=C2)=O
Molecular Formula
C23H27N3O6
Molecular Weight
441.48
References & Citations
[1]Tanaka H, Hashimoto N. A multiple ion channel blocker, NIP-142, for the treatment of atrial fibrillation. Cardiovasc Drug Rev. 2007 Winter;25 (4) :342-56.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
L-type calcium channel; T-type calcium channel

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