MAP4K4-IN-7

• Description:

  MAP4K4-IN-7 (Compound 8) is a MAP4K4 inhibitor. MAP4K4-IN-7 shows moderate inhibitory activity against TNIK, MAP4K4, and MINK1 with pIC50 values of 6.8, 6.8, and 6.7 respectively. MAP4K4-IN-7 can be used for the researches of cancer and neurological disease, such as schizophrenia[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  MAP4K

• Related Pathways:

  MAPK/ERK Pathway

• Field of Research:

  Cancer; Neurological Disease

• Smiles:

  FC1=NC=CC(C2=NC3=C(N)N=CN=C3C=C2)=C1

• Molecular Formula:

  C12H8FN5

• Molecular Weight:

  241.22

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations:

  [1]Read J, et al. Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase. Bioorg Med Chem Lett. 2019 Aug 1;29 (15) :1962-1967.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound2

• Clinical Information:

  No Development Reported

• Isoform:

  MAP4K4/HGK; MAP4K6/MINK1; MAP4K7/TNIK

• CAS Number:

  [1499162-60-5]