MAP4K4-IN-6

• UNSPSC Description:

  MAP4K4-IN-6 (Compound 15f) is a MAP4K4 inhibitor (IC50: 80 nM). MAP4K4-IN-6 reduces the c-Jun phosphorylation. MAP4K4-IN-6 has neuroprotective effects. MAP4K4-IN-6 increases the viability of motor neurons. MAP4K4-IN-6 can be used for research of Amyotrophic lateral sclerosis (ALS)[1].

• Target Antigen:

  JNK; MAP4K

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/map4k4-in-6.html

• Smiles:

  O=C(NC)C(S1)=C(NC(N)=O)C=C1C2=CC=C(C(F)(F)F)C=C2

• Molecular Weight:

  343.32

• References & Citations:

  [1]Hattori H, et al. Discovery of 5-phenyl-3-ureidothiophene-2-carboxamides as protective agents for ALS patient iPSC-derived motor neur

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported