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UNC8969

CAT: 0931-T202988-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T202988-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
TAM Receptor
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
UNC8969 is a macrocyclic dual MERTK/AXL inhibitor (IC50 MERTK = 1.1 nM; IC50 AXL = 5.3 nM) . The compound exhibits low nanomolar activity against MERTK and AXL while demonstrating good selectivity over TYRO3 and FLT3. Target binding and selectivity have been confirmed through NanoBRET and cell-based MERTK and AXL phosphorylation assays. UNC8969 possesses excellent pharmacokinetic properties (large AUC and long half-life) and shows exceptional anti-tumor activity against lung cancer cell lines, indicating its potential as a therapeutic compound.
Smiles
CC1=CC=C(N2)C=C1OC/C=C\CNC3=NC2=C(C(N[C@@H]4CC[C@@H](C(NCCN(CC)CC)=O)CC4)=O)C=N3
Molecular Formula
C29H41N7O3
Molecular Weight
535.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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