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TNIK&MAP4K4-IN-1

CAT: 0804-HY-156523-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-156523-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TNIK&MAP4K4-IN-1 (compound A-39) is a dual inhibitor of TNIK and MAP4K4/HGK with IC50s of 1.29 nM and [1].
CAS Number
2478592-86-6
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tnik-map4k4-in-1.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCCC4)O1)NC5=C(OC)C=NC=C5
Molecular Formula
C25H23FN4O3
Molecular Weight
446.47
References & Citations
[1]Aliper A, et al. TNIK and/or MAP4K4 kinase inhibitors and therapeutic uses thereof in treatment of cancer and fibrosis. World Intellectual Property Organization, WO2020170203 A1 2020-08-27.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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