YVAD-CHO (TFA)

• Description:

  YVAD-CHO TFA is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor (Ki: 0.76 nM) . YVAD-CHO TFA inhibits mature IL-1β production. YVAD-CHO TFA partially delays motoneurone death in lesioned facial nerve mice[1][2].

• UNSPSC:

  12352209

• Target:

  Caspase; Interleukin Related

• Related Pathways:

  Apoptosis; Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Smiles:

  O=C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C=O)=O)=O)[C@H](CC1=CC=C(C=C1)O)N.FC(C(O)=O)(F)F.[x]

• Molecular Weight:

  450.49 (free base)

• References & Citations:

  [1]de Bilbao F, et al. Acute application of an interleukin-1 beta-converting enzyme-specific inhibitor delays axotomy-induced motoneurone death. Neuroreport. 1996 Nov 25;7 (18) :3051-4.|[2]Laliberte RE, et al. ATP treatment of human monocytes promotes caspase-1 maturation and externalization. J Biol Chem. 1999 Dec 24;274 (52) :36944-51.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported