Ac-YVAD-CHO (acetate)

Ac-YVAD-CHO (acetate)

• UNSPSC Description: Ac-YVAD-CHO (L-709049) acetate is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO acetate is also a caspase-1 inhibitor. Ac-YVAD-CHO acetate can suppress the production of mature IL-lβ[1][2][3].
• Target Antigen: Apoptosis; Caspase; Interleukin Related
• Type: Reference compound
• Related Pathways: Apoptosis;Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/ac-yvad-cho-acetate.html
• Solubility: 10 mM in DMSO
• Smiles: OC(C=C1)=CC=C1C[C@H](NC(C)=O)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@H](C=O)CC(O)=O)=O)=O)=O.CC(O)=O
• Molecular Weight: 552.57
• References & Citations: [1]Fletcher DS, et al. A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta production in vitro and in vivo. J Interferon Cytokine Res. 1995;15(3):243-248. |[2]Cao Y, et al. Caspase-1 inhibitor Ac-YVAD-CHO attenuates quinolinic acid-induced increases in p53 and apoptosis in rat striatum. Acta Pharmacol Sin. 2005 Feb;26(2):150-4. |[3]Zhou X, et al. Nitric oxide induces thymocyte apoptosis via a caspase-1-dependent mechanism. J Immunol. 2000 Aug 1;165(3):1252-8.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported