Ac-LEVD-CHO (TFA)

• Description:

  Ac-LEVD-CHO (TFA) is an inhibitor of caspase-4. Ac-LEVD-CHO (TFA) can inhibit the expression and secretion of IL-1α expression as well as the activation of caspase-4 induced by the T. denticola periodontal pathogen surface protein Td92 in human gingival fibroblasts. Ac-LEVD-CHO (TFA) can also reduce the apoptosis due to the expression of the dominant negative adenoviral RNA-dependent protein kinase in A549 and PC3 cancer cell lines[1][2].

• UNSPSC:

  12352209

• Target:

  Apoptosis; Caspase

• Related Pathways:

  Apoptosis

• Field of Research:

  Cancer

• Smiles:

  OC(C[C@@H](C=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(C)C)=O)=O)=O)=O.FC(C(O)=O)(F)F

• Molecular Formula:

  C24H37F3N4O11

• Molecular Weight:

  614.57

• References & Citations:

  [1]Jun, H. K., et al., (2018) . Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts. Cell death and differentiation, 25 (2), 380–391.|[2]Pataer, A., et al., (2009) . Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity. Cancer biology & therapy, 8 (3), 245–252.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported