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Ac-LEVD-CHO (TFA)

CAT: 0804-HY-136727ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-136727ASize:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ac-LEVD-CHO (TFA) is an inhibitor of caspase-4. Ac-LEVD-CHO (TFA) can inhibit the expression and secretion of IL-1α expression as well as the activation of caspase-4 induced by the T. denticola periodontal pathogen surface protein Td92 in human gingival fibroblasts. Ac-LEVD-CHO (TFA) can also reduce the apoptosis due to the expression of the dominant negative adenoviral RNA-dependent protein kinase in A549 and PC3 cancer cell lines[1][2].
UNSPSC
12352209
Target
Apoptosis; Caspase
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
OC(C[C@@H](C=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(C)C)=O)=O)=O)=O.FC(C(O)=O)(F)F
Molecular Formula
C24H37F3N4O11
Molecular Weight
614.57
References & Citations
[1]Jun, H. K., et al., (2018) . Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts. Cell death and differentiation, 25 (2), 380–391.|[2]Pataer, A., et al., (2009) . Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity. Cancer biology & therapy, 8 (3), 245–252.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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