Boc-AEVD-CHO (TFA)

• Description :

  Boc-AEVD-CHO TFA is a Caspase 8 inhibitor. Boc-AEVD-CHO TFA significantly increases the frequencies of Nocodazole (HY-13520) or methyl methane sulfonate (MMS) induced micronuclei (MN) and micronucleated binucleates (MNCB) in PBMC by inhibiting cell apoptosis. Boc-AEVD-CHO TFA can be used for immune and inflammatory diseases research[1].

• UNSPSC :

  12352209

• Target :

  Apoptosis; Caspase

• Related Pathways :

  Apoptosis

• Field of Research :

  Inflammation/Immunology

• Smiles :

  C[C@H](NC(OC(C)(C)C)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@H](C=O)CC(O)=O)=O)=O)=O.FC(C(O)=O)(F)F.[x]

• Molecular Formula :

  C22H36N4O10.xC2HF3O2

• Molecular Weight :

  516.54 (free base)

• References & Citations :

  [1]Decordier I, et al. Influence of caspase activity on micronuclei detection: a possible role for caspase-3 in micronucleation. Mutagenesis. 2005 May;20 (3) :173-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  Caspase 8