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Calciseptine (TFA)

CAT: 0804-HY-P3269ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P3269ASize:1 Each
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Calciseptine TFA is a natural peptide toxin found in the venom of the black mamba snake (Dendroaspis p. polylepis) . Calciseptine TFA is a highly effective and selective blocker of the L-type channel of the Cav1.2 subtype, with an IC50 value of 92 nM. Calciseptine TFA has no effect on Cav3.1, Cav2.2, Cav2.1, Cav1.1, voltage-sensitive sodium channels and potassium channels. Calciseptine TFA has negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine TFA can be used for the study of cardiovascular diseases[1].
UNSPSC
12352209
Target
Calcium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
O=C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CCCCN)C(N[C@@H](CCSC)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(NC4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC5=O)C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC7=CNC=N7)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N8[C@@H](CCC8)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H](C(NCC(N[C@@H](CSSC[C@@H](C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(O)=O)=O)=O)NC9=O)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CC(O)=O)C(N[C@H]9CCCNC(N)=N)=O)=O)=O)=O)=O)NC%10=O)C(N%11[C@@H](CCC%11)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H](CC%12=CNC%13=CC=CC=C%12%13)C(N%14[C@@H](CCC%14)C(N[C@@H](CC%15=CC=C(C=C%15)O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@H]%10CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC4=O)C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@H]5[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N.O=C(O)C(F)(F)F.[x]
Molecular Formula
C299H468N90O87S10.xC2HF3O2
Molecular Weight
7036.12 (free base)
References & Citations
[1]Mesirca P, et al. Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine. Nat Commun. 2024 Jan 2;15 (1) :54.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
L-type calcium channel

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