Calciseptine

• Description :

  Calciseptine Catalog number: MDP0631 CAS Number: 176591-49-4 Sequence: Arg-Ile-Cys-Tyr-Ile-His-Lys-Ala-Ser-Leu-Pro-Arg-Ala-Thr-Lys-Thr-Cys-Val-Glu-Asn-Thr-Cys-Tyr-Lys-Met-Phe-Ile-Arg-Thr-Gln-Arg-Glu-Tyr-Ile-Ser-Glu-Arg-Gly-Cys-Gly-Cys-Pro-Thr-Ala-Met-Trp-Pro-Tyr-Gln-Thr-Glu-Cys-Cys-Lys-Gly-Asp-Arg-Cys-Asn-Lys (Disulfide bonds between Cys3-Cys22, Cys17-Cys39, Cys41-Cys52, and Cys53-Cys58) Amount: 100 ug Molecular Weight: 7036 g/mol Supplied as: Powder Applications: molecular tool for various biochemical applications Storage: -20 °C WARNING: For in vitro Research Use Only. NOT for use on humans or animals. Grade: Biotechnology grade. All products are highly pure. References: 1: García MC, Hernández-Gallegos Z, Escamilla J, Sánchez JA. Calciseptine, a Ca2+ channel blocker, has agonist actions on L-type Ca2+ currents of frog and mammalian skeletal muscle J Membr Biol. 2001 Nov 15;184(2):121-9. 2: de Weille JR, Schweitz H, Maes P, Tartar A, Lazdunski M. Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2437-40. 3: Yasuda O, Morimoto S, Chen Y, Jiang B, Kimura T, Sakakibara S, Koh E, Fukuo K, Kitano S, Ogihara T. Calciseptine binding to a 1,4-dihydropyridine recognition site of the L-type calcium channel of rat synaptosomal membranes Biochem Biophys Res Commun. 1993 Jul 30;194(2):587-94. 4: Watanabe TX, Itahara Y, Kuroda H, Chen YN, Kimura T, Sakakibara S. Smooth muscle relaxing and hypotensive activities of synthetic calciseptine and the homologous snake venom peptide FS2 Jpn J Pharmacol. 1995 Jul;68(3):305-13. 5: Kini RM, Caldwell RA, Wu QY, Baumgarten CM, Feher JJ, Evans HJ. Flanking proline residues identify the L-type Ca2+ channel binding site of calciseptine and FS2 Biochemistry. 1998 Jun 23;37(25):9058-63. 6: Teramoto N, Ogata R, Okabe K, Kameyama A, Kameyama M, Watanabe TX, Kuriyama H, Kitamura K. Effects of calciseptine on unitary barium channel currents in guinea-pig portal vein Pflugers Arch. 1996 Jul;432(3):462-70. 7: Tokumaru H, Satoh Y, Hirashima N, Shojaku S, Yamamoto H, Kirino Y. Involvement of calciseptine-sensitive calcium channels in the evoked acetylcholine release from electric organ synaptosomes Biol Pharm Bull. 1997 Jun;20(6):641-5. 8: Imanishi T, Matsushima K, Kawaguchi A, Wada T, Yoshida S, Ichida S. Increased response to high KCl-induced elevation in the intracellular-Ca(2+) concentration in differentiated NG108-15 cell and the inhibitory effect of the L-type Ca(2+) channel blocker, calciseptine Neurochem Res. 2006 Jan;31(1):33-40. 9: Rogers CM, Brown ER. Differential sensitivity to calciseptine of L-type Ca(2+) currents in a 'lower' vertebrate (Scyliorhinus canicula), a protochordate (Branchiostoma lanceolatum) and an invertebrate (Alloteuthis subulata) Exp Physiol. 2001 Nov;86(6):689-94. 10: Kuroda H, Chen YN, Watanabe TX, Kimura T, Sakakibara S. Solution synthesis of calciseptine, an L-type specific calcium channel blocker Pept Res. 1992 Sep-Oct;5(5):265-8.
  Products Related to Calciseptine can be found at Peptides

• Short Description :

  Catalog Number: MDP0631 (100 ug)

• Weight :

  0.15

• Length :

  2

• Width :

  0.5

• Height :

  0.5