Calciseptine

• Description :

  Calciseptine is a natural polypeptide toxin found in the venom of the black mamba snake (Dendroaspis p. polylepis) . Calciseptine is a highly effective and selective blocker of the L-type channel of the Cav1.2 subtype, with an IC50 value of 92 nM. Calciseptine has no effect on Cav3.1, Cav2.2, Cav2.1, Cav1.1, voltage-sensitive sodium channels and potassium channels. Calciseptine exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine can be used for research on cardiovascular diseases[1].

• CAS Number :

  [178805-91-9]

• UNSPSC :

  12352209

• Target :

  Calcium Channel

• Type :

  Peptides

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/calciseptin.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@@H](N)CCCNC(N)=N)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2[C@@H](C)O)=O)CC(N)=O)=O)CCC(O)=O)=O)C(C)C)=O)CSSC[C@H](N3)C(NCC(N[C@H](C(N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N5[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]6CCC(O)=O)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CC7=CC=C(O)C=C7)=O)CCC5)=O)CC8=CNC9=CC=CC=C89)=O)CCSC)=O)C)=O)[C@@H](C)O)=O)CCC4)=O)CSSC[C@H](NC6=O)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H]%10CCCNC(N)=N)=O)CC(O)=O)=O)=O)CCCCN)=O)CSSC[C@H](NC%10=O)C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CC(N)=O)=O)=O)=O)=O)=O)[C@@H](C)O)=O)CCCCN)=O)[C@@H](C)O)=O)C)=O)CCCNC(N)=N)=O)CCC1)=O)CC(C)C)=O)CO)=O)C)=O)CCCCN)=O)CC%11=CNC=N%11)=O)[C@H](CC)C)=O)CC%12=CC=C(O)C=C%12)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC3=O)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)CO)=O)[C@H](CC)C)=O)CC%13=CC=C(O)C=C%13)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)CC%14=CC=CC=C%14)=O)CCSC)=O)CCCCN)=O)CC%15=CC=C(O)C=C%15)=O)=O)[C@H](CC)C

• Molecular Formula :

  C299H468N90O87S10

• Molecular Weight :

  7036.12

• References & Citations :

  [1]Mesirca P, et al. Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine. Nat Commun. 2024 Jan 2;15 (1) :54.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  L-type calcium channel