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Calciseptine

CAT: 0804-HY-P3269Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P3269Size:1 Each
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Description
Calciseptine is a natural polypeptide toxin found in the venom of the black mamba snake (Dendroaspis p. polylepis) . Calciseptine is a highly effective and selective blocker of the L-type channel of the Cav1.2 subtype, with an IC50 value of 92 nM. Calciseptine has no effect on Cav3.1, Cav2.2, Cav2.1, Cav1.1, voltage-sensitive sodium channels and potassium channels. Calciseptine exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine can be used for research on cardiovascular diseases[1].
CAS Number
178805-91-9
UNSPSC
12352209
Target
Calcium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/calciseptin.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)CCCNC(N)=N)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2[C@@H](C)O)=O)CC(N)=O)=O)CCC(O)=O)=O)C(C)C)=O)CSSC[C@H](N3)C(NCC(N[C@H](C(N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N5[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]6CCC(O)=O)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CC7=CC=C(O)C=C7)=O)CCC5)=O)CC8=CNC9=CC=CC=C89)=O)CCSC)=O)C)=O)[C@@H](C)O)=O)CCC4)=O)CSSC[C@H](NC6=O)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H]%10CCCNC(N)=N)=O)CC(O)=O)=O)=O)CCCCN)=O)CSSC[C@H](NC%10=O)C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CC(N)=O)=O)=O)=O)=O)=O)[C@@H](C)O)=O)CCCCN)=O)[C@@H](C)O)=O)C)=O)CCCNC(N)=N)=O)CCC1)=O)CC(C)C)=O)CO)=O)C)=O)CCCCN)=O)CC%11=CNC=N%11)=O)[C@H](CC)C)=O)CC%12=CC=C(O)C=C%12)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC3=O)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)CO)=O)[C@H](CC)C)=O)CC%13=CC=C(O)C=C%13)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)CC%14=CC=CC=C%14)=O)CCSC)=O)CCCCN)=O)CC%15=CC=C(O)C=C%15)=O)=O)[C@H](CC)C
Molecular Formula
C299H468N90O87S10
Molecular Weight
7036.12
References & Citations
[1]Mesirca P, et al. Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine. Nat Commun. 2024 Jan 2;15 (1) :54.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
L-type calcium channel

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