AVLX-144

• Description:

  AVLX-144 is a highly potent inhibitor of postsynaptic density protein 95 (PSD-95) . AVLX-144 can be used as a template to develop imaging probes for postsynaptic density (PSD) molecules, and can be labeled with fluorine-18 (¹⁸F) or tritium (³H) to visualize PSD-95 in vivo. AVLX-144 can be utilized for the study of Parkinson's disease[1].

• UNSPSC:

  12352209

• Target:

  IGluR

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Smiles:

  CC(C)[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC(CCOCCOCCN(CCOCCOCCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O)C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](N)CC1=CC=C(C=C1)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula:

  C126H221N43O41

• Molecular Weight:

  2994.37

• References & Citations:

  [1]Wu B, et al. A spatiotemporal atlas of cholestatic injury and repair in mice. Nat Genet. 2024 May;56 (5) :938-952.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [1413933-25-1]