LEB-03-144

• Description:

  LEB-03-144 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C3 alkyl linker. LEB-03-144 shows significant WEE1 stabilization in HEP3B hepatoma cancer cells[1].

• UNSPSC:

  12352005

• Target:

  Wee1

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/leb-03-144.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C=CCN1C(C2=C(N1C3=NC(C(C)(O)C)=CC=C3)N=C(N=C2)NC4=CC=C(C=C4)N5CCN(CC5)CCCNC(CCC6=CC=C(O6)N7CCN(CC7=O)C(C=C)=O)=O)=O

• Molecular Formula:

  C43H51N11O6

• Molecular Weight:

  817.94

• References & Citations:

  [1]Henning NJ, et al. Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol. 2022 Apr;18 (4) :412-421.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2858812-89-0