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Antibacterial agent 144

CAT: 0804-HY-155060Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155060Size:1 Each
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Description
Antibacterial agent 144 (compound 8e) is an antibacterial agent, with better effect against multi-resistant Staphylococcus aureus than Chloromycin and Amoxicillin. Antibacterial agent 144 destroys the cytoplasmic membrane of bacteria, and inhibits the biofilms formation. Antibacterial agent 144 binds to HSA (Kd=13.2 μM), and exerts bactericidal efficacy. Antibacterial agent 144 also binds with DNA to for supramolecular complex to obstruct DNA replications[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
Bacterial; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antibacterial-agent-144.html
Solubility
10 mM in DMSO
Smiles
O=C(N(NC1=NC(NCC2=CC=CC=C2)=NC(N3CCOCC3)=N1)C4=O)C5=C(C4=CC=C6)C6=CC=C5
Molecular Formula
C26H23N7O3
Molecular Weight
481.51
References & Citations
[1]Gupta S, et al. Membrane-active substituted triazines as antibacterial agents against Staphylococcus aureus with potential for low drug resistance and broad activity. Eur J Med Chem. 2023 Oct 5;258:115551.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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