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Hydrostatin-TL1

CAT: 0804-HY-P11214Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P11214Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hydrostatin-TL1 (H-TL1), a nine-amino-acid peptide, is a TNF-α antagonist. Hydrostatin-TL1 can be isolated from the venom gland of sea snake Hydrophis cyanocinctus. H-TL1 competitively inhibits the interaction between TNF-α/TNFR1 and attenuates the cytotoxicity and inflammation of TNF-α. Hydrostatin-TL1 can be used for TNF-α-associated inflammatory diseases, such as rheumatoid arthritis, osteoporosis and inflammatory bowel disease (IBD) research[1].
CAS Number
2243975-43-9
Product Name Alternative
H-TL1
UNSPSC
12352209
Target
ERK; Integrin; Interleukin Related; JNK; NF-κB; p38 MAPK; TNF Receptor
Related Pathways
Apoptosis; Cytoskeleton; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Molecular Formula
C39H71N11O13S
Molecular Weight
934.11
References & Citations
[1]Wang N, et al. Hydrostatin-TL1, an Anti-Inflammatory Active Peptide from the Venom Gland of Hydrophis cyanocinctus in the South China Sea. Int J Mol Sci. 2016 Nov 22;17 (11) :1940.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
ERK; IL-8; JNK; p38 MAPK

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