TL13-12

• Description:

  TL13-12 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC50 value of 0.69 nM. TL13-12 also prompts the degradation of additional kinases including Aurora A, FER, PTK2, and RPS6KA1 with IC50 values of 13.5 nM, 5.74 nM, 18.4 nM, and 65 nM, respectively. TL13-12 is comprised of the conjugation of TAE684 (HY-10192) and the Cereblon ligand of Pomalidomide (HY-10984) [1].

• UNSPSC:

  12352005

• Target:

  Anaplastic lymphoma kinase (ALK) ; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tl13-12.html

• Concentration:

  10mM

• Purity:

  98.16

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(NCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3)C(OC)=C2)CC1)CNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O

• Molecular Formula:

  C45H53ClN10O10S

• Molecular Weight:

  961.48

• References & Citations:

  [1]Powell CE, et al. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK) .J Med Chem. 2018 May 10;61 (9) :4249-4255.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Cereblon

• CAS Number:

  2229037-04-9