TL13-110

• Description :

  TL13-110 is a negative control for TL13-112 (HY-123919) and a potent ALK inhibitor with an IC50 of 0.34 nM. TL13-110 does not degrade ALK in cells[1].

• UNSPSC :

  12352005

• Target :

  Anaplastic lymphoma kinase (ALK)

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/tl13-110.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NCCOCCOCCN1CCC(C2=CC(OC(C)C)=C(NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3)C=C2C)CC1)CNC5=CC=CC(C(N6C7C(NCCC7)=O)=O)=C5C6=O

• Molecular Formula :

  C49H62ClN9O9S

• Molecular Weight :

  988.59

• References & Citations :

  [1]Chelsea E Powell, et al. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK) . J Med Chem. 2018 May 10;61 (9) :4249-4255.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2229037-09-4]