TL1A/TNFSF15, Mouse

• UNSPSC Description:

  The TL1A protein (VEGI protein), belongs to the tumor necrosis factor (TNF) family and is a receptor for TNFRSF25 and TNFRSF6B. TL1A is involved in the activation of NF-κB and C-Jun pathways, which can be used as a regulator of mucosal immunity and participate in the immune pathway of inflammatory bowel disease (IBD) pathogenesis[1][2]. TL1A originates from endothelial cells and inhibits the proliferation of breast cancer, epithelial and myeloid tumor cells[3]. The mouse TL1A protein has a transmembrane domain (40-60 a.a.) that can be cleaved into membrane-type and soluble peptide fragments. TL1A/TNFSF15 Protein, Mouse is the extracullar part of TL1A protein (I76-L252), produced in E.coli with tag free.

• Type:

  Recombinant Proteins

• Assay Protocol:

  https://www.medchemexpress.com/cytokines/tl1a-tnfsf15-protein-mouse.html

• Purity:

  95.0

• Smiles:

  ITEERSEPSP QQVYSPPRGK PRAHLTIKKQ TPAPHLKNQL SALHWEHDLG MAFTKNGMKY INKSLVIPES GDYFIYSQIT FRGTTSVCGD ISRGRRPNKP DSITVVITKV ADSYPEPARL LTGSKSVCEI SNNWFQSLYL GAMFSLEEGD RLMVNVSDIS LVDYTKEDKT FFGAFLL

• Molecular Weight:

  22 kDa

• References & Citations:

  [1]Furfaro F, et al. TL1A: A New Potential Target in the Treatment of Inflammatory Bowel Disease. Curr Drug Targets. 2021;22(7):760-769.|[2]Migone TS, et al. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity. 2002 Mar;16(3):479-92.|[3]Haridas V, et al. VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth. Oncogene. 1999 Nov 11;18(47):6496-504.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Stored at -20°C for 2 years