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WT1 126-134 peptide

CAT: 0804-HY-P11084Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P11084Size:1 Each
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Description
WT1 126-134 peptide is a Wilms' tumor oncogene protein (WT1) peptide (RMFPNAPYL) . WT1 126-134 peptide is presented by HLA-A0201 and induces cytotoxic CD8 T cells capable of killing WT1+ positive tumor cells. WT1 126-134 can form stable complexes with the H-2Db (mouse) or HLA-A0201 (human) molecules. WT1 126-134 peptide/HLA-A0201 complex has an extremely high affinity (Kd = 0.2 nM) with the humanized monoclonal antibody (IgG1) . WT1 126-134 peptide can be used as a vaccine for T cells or as a target for antibodies[1][2][3].
CAS Number
256952-63-3
UNSPSC
12352209
Target
MHC
Related Pathways
Immunology/Inflammation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(N[C@@H](CCSC)C(N[C@@H](CC1=CC=CC=C1)C(N2[C@@H](CCC2)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N
Molecular Formula
C52H77N13O12S
Molecular Weight
1108.31
References & Citations
[1]Shirakawa T, Kitagawa K. Antitumor effect of oral cancer vaccine with Bifidobacterium delivering WT1 protein to gut immune system is superior to WT1 peptide vaccine. Hum Vaccin Immunother. 2018 Jan 2;14 (1) :159-162.|[2]David A, et al, A Cytotoxic Human Monoclonal Antibody Recognizing Cell Surface WT1 Peptide/HLA-A2 Complexes. Blood 2011; 118 (21) : 1677.|[3]Nakajima H, et al. Identification of mouse helper epitopes for WT1-specific CD4+ T cells. Cancer Immunol Immunother. 2021 Nov;70 (11) :3323-3335.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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