MCC-134

• Description :

  MCC-134, a blocker of mitochondrial and opener of surface ATP-sensitive K+ (KATP) channels, abrogates cardioprotective effects of chronic hypoxia. MCC-134 is a vasorelaxing agent[1][2].

• UNSPSC :

  12352005

• Target :

  Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/mcc-134.html

• Smiles :

  S=C(NC)C1(CCC1)C(C2=CC=C(C=C2)N3C=CN=C3)=O

• Molecular Formula :

  C16H17N3OS

• Molecular Weight :

  299.39

• References & Citations :

  [1]F Kolár, et al. MCC-134, a blocker of mitochondrial and opener of sarcolemmal ATP-sensitive K+ channels, abrogates cardioprotective effects of chronic hypoxia. Physiol Res. 2005;54 (4) :467-71.|[2]Norihito Sasaki, et al. MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning. Circulation. 2003 Mar 4;107 (8) :1183-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [181238-67-5]