Products for Research Use Only
RegisterLogin

GTx-134

CAT: 0804-HY-13312ASize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13312ASize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GTx-134 is a dual insulin-like growth factor 1 receptor/insulin receptor (IGF-1R/IR) inhibitor with an IC50 values for IGF-1R and IR of 97 and 187 nM respectively. GTx-134 inhibits the autophosphorylation of IGF-1R and its downstream signaling pathway (Akt), thereby blocking the proliferation and survival signals of tumor cells. GTx-134 has broad-spectrum inhibitory activity against multiple myeloma cell lines and can induce apoptosis in sensitive cells. GTx-134 significantly inhibits tumor growth in mice with MM1.S cell transplantation. GTx-134 works in synergy with existing therapies (such as protease preparations, immunomodulators) . GTx-134 can be used in high-risk myeloma research[1].
CAS Number
1008448-19-8
UNSPSC
12352005
Target
Akt; Apoptosis; IGF-1R; Insulin Receptor
Related Pathways
Apoptosis; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC(C=C(C=C1)C)=C1OC[C@H](O)CNC2=C(C(NC=C2)=O)C3=NC(C=C4C(C(N(C5CCN(CC5)CCS(C)(=O)=O)C4)=O)=C6)=C6N3
Molecular Formula
C33H40N6O6S
Molecular Weight
648.77
References & Citations
[1]Liang SB, et al. Molecular target characterization and antimyeloma activity of the novel, insulin-like growth factor 1 receptor inhibitor, GTx-134. Clin Cancer Res. 2011 Jul 15;17 (14) :4693-704.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-111061-01GTX-758
HY-171048-01GTx-027
HY-12023-01GTx-007
HY-141810MT-134
HY-168623EGFR-IN-134
HY-156996AGI-134
HY-119306MCC-134
HY-100594-01EUK-134
HY-172940TBP-134
HY-D0351-01Fluorescent Brightener 134

Alternative Products

CatalogName
T204549-01GTx-027
MBS5810856GTX-758
MBS384842-01Andarine (GTX-007)
A10076-25Andarine (GTX-007) 25mg
A10076-50Andarine (GTx-007) 50mg
A10076-100Andarine (GTx-007) 100mg
A10076-10Andarine (GTx-007) 10mg
A10076-5Andarine (GTx-007) 5mg
MBS576471MK-2866 (GTx-024)
GTR19154693-01Ostarine (MK-2866, GTx-024)

Popular Products